Integrated approach

Continual Salmonella vaccination is a key component in achieving an effective, permanent reduction in Salmonella infection pressure throughout the herd. For an effective reduction in Salmonella pressure, both sows and piglets should ideally be vaccinated. In sows, vaccination prevents or significantly reduces the shedding of wild strains of Salmonella Typhimurium during lactation, leading to a lower risk of infection for the piglets. The aim of vaccination in piglets is to reduce the colonization and shedding of the pathogen in order to prevent animal-to-animal infection. Any clinical symptoms present are suppressed when you vaccinate pigs.

For a lasting reduction in Salmonella infection pressure and a permanent improvement in farm category, continual Salmonella vaccination is required until only vaccinated pigs remain in the herd.

After this, continuing Salmonella vaccination of sows is recommended. The Salmonella vaccination should be accompanied by appropriate hygiene measures (cleaning and disinfection, rodent and pest control, monitoring of farm procedures and working routes). Repeated testing of the herd (faeces swabs, environmental samples, swipe samples) should accompany Salmonella vaccination to help ensure long-term success when you vaccinate pigs.

All three pillars – hygiene, vaccination and management – are important to solve the salmonella problem in your herd. If one of the pillars is neglected or not considered at all, success will be hampered, if not made impossible.

Initial situation

Infected pig herd

  • extent of shedding increases
  • environment gets more and more contaminated
  • hygiene measures are not sufficiently effective
  • carry-over between different compartments 
  • temporary increased use of acids has no sustainable effect

Unvaccinated flock

The situation becomes worse

  • high risk of slipping into the worst category in countries with a salmonella monitoring system
  • clinical signs such as diarrhoea after weaning may occur
  • temporary use of antibiotics may be necessary to combat clinical signs

Vaccinated flock

the situation is stabilised

  • continuous vaccination and accompanying measures reduce the prevalence of salmonella 
  • clinical signs disappear
  • infectious pressure is highly reduced
  • end of piglet vaccination
  • maintaining sow and gilt vaccination


Vaccination with a live-attenuated Salmonella Typhimurium vaccine


vaccinated pigs against Salmonella Typhimurium plus monophasic serovars


tool in your hands, reducing colonisation and shedding of vaccinated pigs


prevents clinical disease, reducing use of high cost antibiotics and acids

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Four easy steps

Your success plan in four easy steps

Define objective

Agree on individual objectives to solve the specific Salmonella problem of your pig holding.
Ceva’s technical service supports you with experience and knowledge.

Determine status

Inspect the pig farm. Analyse and record weak points. Take samples.
Use the tools which are provided by Ceva, e. g. the checklist and the sampling kit.

Define measures

Create an action plan including the Salmonella vaccination schedule and further measures.
Convenient piglet Salmonella vaccination with the drencher kit provided by Ceva.

Control progress

Check the effects of your measures regularly and optimize them if necessary.
Ceva’s technical service supports you in interpreting of the laboratory results.

How to vaccinate

After 28 weeks, all sows and progeny of the herd have received Salmonella vaccination. A lasting reduction in infection pressure means low serum antibody levels.

Each icon corresponds to a group of animals in a 3-week batch system.

Vaccination schedule

Vaccination schedule with a live-attenuated Salmonella Typhimurium vaccine

Immunity develops within 2 weeks of completing the Salmonella vaccination course.

Duration of immunity:

In sows 24 weeks
In fatteners 19 weeks

Antibiotic use should be discontinued for five days before and five days after Salmonella vaccination.
If such treatment is essential, the pigs should be vaccinated five days later at the earliest.

Vaccination Application

Subcutaneous vaccination of sows and gilts

  • Fill the system completely with the vaccine.
  • The needle should have a maximum length of 2.5 cm (1 inch) and be directed downwards in a perpendicular direction to the sow.
  • Gentle patting at the injection site prior to the vaccination helps to avoid defence movements of the sow.

Oral vaccination of suckling piglets and weaners with a drencher with bottle mount adapter

The Salmonella Drencher Kit contains a detailed guideline how to resolve the vaccine and how to prepare the drencher.

Oral vaccination of suckling piglets and weaners with a drencher with bottle mount adapter

The Salmonella Drencher Kit contains a detailed guideline how to resolve the vaccine and how to prepare the drencher.


Combined vaccination stops clinical signs ²

  • Best reduction of shedding of the challenge strain and infectious pressure,
  • and fastest elimination of diarrhoea

when you vaccinate both sows and piglets.

The three study groups consisted of Salmonella-free sows and piglets. A Salmonella Typhimurium DT104 strain was used to infect the pigs. The sows received the Salmonella vaccination subcutaneously 6 and 3 weeks ante partum; the piglets received the Salmonella vaccination orally on day 3 and at the age of 4 weeks. The animals were infected in week 7 using a stomach tube.

Longitudinal vaccination reduces antibody titre and detection rate ³

  • Significant reduction of the detection rate,
  • no more antibiotic treatment against salmonella necessary,
  • and highly reduced antibody titres

when sows and piglets were vaccinated over a period of 18 months.

Over a period of 1.5 years, 575 sows and their offspring (16,356 piglets) were vaccinated in a herd with clinical Salmonellosis.

Salmonella vaccination schedule for sows and gilts: 3 and 6 weeks subcutaneous ante partum.

Salmonella vaccination schedule for piglets (differs from SPC): day 21 oral, week 7 IM.

Cultural detection of ­Salmonella Typhimurium field strain in intestinal lymph nodes of slaughter pigs.

Serological antibody detection. Proportion of positive samples after testing; 40 serum samples in each case.

Vaccination improves daily weight gain

  • Significantly higher daily weight gain,
  • less excretion of salmonella,
  • and a lower specific mean antibody titre

when piglets were vaccinated under a salmonella monitoring program.

Daily weight gain between 3 days and 29 weeks of age. Within each herd, 120 piglets received oral Salmonella vaccination at 3 and 24 days of age; 120 piglets were left unvaccinated as control group.

2 Stief, M., Diss. Leipzig 2008
3 T.Lindtner et all, Die Immunprophylaxe – ein Beitrag zur Bekämpfung von Salmonella Typhimurium, Infektionen beim Schwein; Tierärztl. Praxis, 30 (G), 392 – 394, 2002
4 L.De Ridder et al, Usefulness of a live Salmonella Typhimurium vaccine to control Salmonella Infections on farrow-to-finish pig herds; The Veterinary Journal. 2014