Integrated approach

Continual vaccination is a key component in achieving an effective, permanent reduction in Salmonella infection pressure throughout the herd. For an effective reduction in Salmonella pressure, both sows and piglets should ideally be vaccinated. In sows, vaccination prevents or significantly reduces the shedding of wild strains of Salmonella Typhimurium during lactation, leading to a lower risk of infection for the piglets. The aim of vaccination in piglets is to reduce the colonization and shedding of the pathogen in order to prevent animal-to-animal infection. Any clinical symptoms present are suppressed.

For a lasting reduction in Salmonella infection pressure and a permanent improvement in farm category, continual vaccination is required until only vaccinated animals remain in the herd.
After this, continuing sow vaccination is recommended. Vaccination should be accompanied by appropriate hygiene measures (cleaning and disinfection, rodent and pest control, monitoring of farm procedures and working routes). Repeated testing of the herd (feces swabs, environmental samples, swipe samples) should accompany vaccination to help ensure long-term success.

All three pillars – hygiene, vaccination and management – are important to solve the salmonella problem in your herd. If one of the pillars is neglected or not considered at all, success will be hampered, if not made impossible.

Initial situation

Infected pig herd

  • extent of shedding increases
  • environment gets more and more contaminated
  • hygiene measures are not sufficiently effective
  • carry-over between different compartments 
  • temporary increased use of acids has no sustainable effect

Unvaccinated flock

The situation becomes worse

  • high risk of slipping into the worst category in countries with a salmonella monitoring system
  • clinical signs such as diarrhoea after weaning may occur
  • temporary use of antibiotics may be necessary to combat clinical signs

Vaccinated flock

the situation is stabilised

  • continuous vaccination and accompanying measures reduce the prevalence of salmonella 
  • clinical signs disappear
  • infectious pressure is highly reduced
  • end of piglet vaccination
  • maintaining sow and gilt vaccination


Vaccination with a live-attenuated Salmonella Typhimurium vaccine



against Salmonella Typhimurium plus monophasic serovars



tool in your hands, reducing colonisation and shedding



prevents clinical disease, reducing use of high cost antibiotics and acids

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Four easy steps

Your success plan in four easy steps

Define objective

Agree on individual objectives to solve the specific salmonella problem of the pig holding.
Ceva’s technical service supports you with experience and knowledge.

Determine status

Inspect the pig farm. Analyse and record weak points. Take samples.
Use the tools which are provided by Ceva, e. g. the checklist and the sampling kit.

Define measures

Create an action plan including the vaccination schedule and further measures.
The piglet vaccination is convenient with the drencher kit provided by Ceva.

Control progress

Check the effects of your measures regularly and optimize them if necessary.
Ceva’s technical service supports you in interpreting of the laboratory results.

How to vaccinate

After 28 weeks, all sows and progeny of the herd have been vaccinated. A lasting reduction in infection pressure means low serum antibody levels.

Each icon corresponds to a group of animals in a 3-week batch system.

Vaccination schedule 

Vaccination schedule with a live-attenuated Salmonella Typhimurium vaccine

Immunity develops within 2 weeks of completing the vaccination course.

Duration of immunity:

In sows 24 weeks
In fatteners 19 weeks

Antibiotic use should be discontinued for five days before and five days after vaccination.
If such treatment is essential, the animals should be vaccinated five days later at the earliest.

Subcutaneous vaccination of sows and gilts

  • Fill the system completely with the vaccine.
  • The needle should have a maximum length of 2.5 cm (1 inch) and be directed downwards in a perpendicular direction to the sow.
  • Gentle patting at the injection site prior to the vaccination helps to avoid defence movements of the sow.

Oral vaccination of suckling piglets and weaners with a drencher with bottle mount adapter

The Salmonella Drencher Kit contains a detailed guideline how to resolve the vaccine and how to prepare the drencher.


Combined vaccination stops clinical signs ²

  • Best reduction of shedding of the challenge strain and infectious pressure,
  • and fastest elimination of diarrhoea

when both sows and piglets were vaccinated.

The three study groups consisted of salmonella-free sows and piglets. A ­Salmonella Typhimurium DT104 strain was used to infect the animals. The sows were vaccinated subcutaneously 6 and 3 weeks ante partum; the piglets were ­immunised orally on day 3 and at the age of 4 weeks. The animals were ­infected in week 7 using a stomach tube.

Longitudinal vaccination reduces antibody titre and detection rate ³

  • Significant reduction of the detection rate,
  • no more antibiotic treatment against salmonella necessary,
  • and highly reduced antibody titres

when sows and piglets were vaccinated over a period of 18 months.

Over a period of 1.5 years, 575 sows and their offspring (16,356 piglets) were vaccinated in a herd with ­clinical salmonellosis.

Vaccination schedule for sows and gilts: 3 and 6 weeks subcutaneous ante partum.

Vaccination schedule for piglets (differs from SPC): day 21 oral, week 7 IM.

Cultural detection of ­Salmonella Typhimurium field strain in intestinal lymph nodes of slaughter pigs.

Serological antibody detection. Proportion of positive samples after testing; 40 serum samples in each case.

Vaccination improves daily weight gain

  • Best reduction of shedding of the challenge strain and infectious pressure,
  • and fastest elimination of diarrhoea

when both sows and piglets were vaccinated.

Daily weight gain between 3 days and 29 weeks of age. Within each herd, 120 piglets were orally vaccinated at 3 and 24 days of age; 120 piglets were left unvaccinated as control group. 

2 Stief, M., Diss. Leipzig 2008
3 T.Lindtner et all, Die Immunprophylaxe – ein Beitrag zur Bekämpfung von Salmonella Typhimurium, Infektionen beim Schwein; Tierärztl. Praxis, 30 (G), 392 – 394, 2002
4 L.De Ridder et al, Usefulness of a live Salmonella Typhimurium vaccine to control Salmonella Infections on farrow-to-finish pig herds; The Veterinary Journal. 2014